3/16/2023 0 Comments Tmax digital activation![]() ![]() ![]() B) and C) k tr results of WT (B) and NEB KO fibers (C). In the presence of 10 µM CK-2066260 (darker traces) tension recovery is faster than in absence of CK-2066260. Shown is the tension recovery phase following the re-stretch (see Methods for details). T max (tension at pCa 4.5) calcium sensitivity (pCa 50) and Hill coefficient (n H) of WT and KO in 0, 5, and 10 µM CK-2066260.Įffect of CK 2066260 on the rate constant of force redevelopment ( k tr).Ī) Examples of k tr experiments on WT and NEB KO fiber bundles activated at pCa 5.95 before (control) and after the addition of 10 µM CK-2066260. Regardless of genotype, active tensions were significantly increased from ∼800% at the pCa 6.4 to ∼10% at pCa 4.5. B) Relative active tension increase (plotted on a log scale) in 5 and 10 µM of CK over 0 µM of CK at various pCa levels. 6.0, CK-2066260 increased active tension of NEB-KO muscle beyond that of WT. ![]()
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